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Programme 3e année du cycle Ingénieur

Biological Engineering

General objectives :

Application of micro and nanodevices to the field of biology/medecine/biotechnology.

Plan of the course:

  1. I. Introduction to nanobiotechnologies
  2. II. Biosensors
    1. II-1) Surface chemistry
    2. II-2) Transducers
  3. III. Nanoparticles (NPs) in biomedical applications
    1. III-1) Vectors
    2. III-2) Magnetic NPs
    3. III-3) Quantum Dots (QDs) or Semiconductor Nanocrystals (NCs)

General objectives :

To develop the students’ sensitivity towards the physico-chemical laws and interactions regulating the structure of proteins and peptides. To develop the students’ sensitivity to allow them to select the best target for a molecular modification.

Plan of the course:

  1. 1. General aspects of protein engineering
    1. 1.1. Synthesis and modification of a protein
    2. 1.2. Natural protein modifications
    3. 1.3. Site directed mutagenesis
  2. 2. Solid Phase Peptide Synthesis
    1. 2.1. Fundamental aspects of protein synthesis
    2. 2.2. SPPS vs in solution peptide synthesis
    3. 2.3. Solid Phase Peptide Synthesis (SPPS)
  3. 3. Bioconjugation techniques
    1. 3.1. Functional targets for bioconjugation
    2. 3.2. Applications of bioconjugating techniques
    3. 3.3. Bioconjugation on existing functionalities
    4. 3.4. Bioconjugation on added functionalities
    5. 3.5. Cross-linkers
  4. 4. Chemical ligation
    1. 4.1. Native Chemical Ligation (NCL)
    2. 4.2. Sequential Native Chemical Ligation
    3. 4.3. Expressed Protein Ligation (EPL)
    4. 4.4. Sequential Expressed Protein Ligation

General objectives :

  • To dispense to the students the multidisciplinary fundamental scientific teachings but also the necessary scientific methods to assure eventually the direction of a packaging project.
  • Acquire the theoretical and practical control of the management of the processes adapted to the packaging jobs

Plan of the course:

  1. Preliminary module: Tools of conception and desgin
    1. 1. Packaging history
    2. 2. Definition and functions
  2. Module 1: Packaging, graphic development and management
    1. 1. The role of the packaging
    2. 2. The design of the packaging
    3. 3. Market expectations
  3. Module 2: Biodegradation creation, interactions and compatibility packaging-contents
    1. 1. Ecodesign
    2. 2. Life Cycle Assessment
    3. 3. Evolutions, regulation
    4. 4. Raw material selection
  4. Module 3: Audit of the performances of a packaging – Quality of materials

General objectives :

Learning about new concepts, new laws, news devices and techniques coming from microelectronic R&D and their application to the field of biology/medecine/biotechnology.

Plan of the course:

  1. I. Introduction to nanotechnology
  2. II. Nanotechnologies (organization, investment, market…)
  3. III. Micro- Nanofabrication
    1. III-1) Top-down approach
    2. III-2) Bottom-up approach

Enseignements transversaux

Cursus

Engineering Sciences

General objectives :

Learning about laws ruling continous and droplet based microfluidics and recent applications to the field of biology/medecine/biotechnology.

Plan of the course:

  1. I. Introduction to microfluidics (MF)
  2. II. Basics in MF
  3. III. MF components
  4. IV. Micro-total analysis system concept
  5. V. Digital MF

General objectives :

Know the high-speed testing strategies (experimental and virtual) in chemistry and biology, infrastructure, devices and applications in the fields of drug discovery, fine chemicals, and chemical biology.

Plan of the course:

  1. 1. Biological high throughput screening
  2. 2. Miniaturization and automation bioassay: Example of inhibitors of ricin
  3. 3. Combinatorial Chemistry: parallel synthesis broadband
  4. 4. Synthesis on solid support: resins
  5. 5. Parallel Synthesis solution supported reagents and "scavengers"
  6. 6. Summary of targeted compound libraries and virtual screening
  7. 7. Systems and robotic equipment, the Lims
  8. 8. Applications to search for chemical catalysts via immunological systems

General objectives :

Be able to integrate the question of “Responsibility” in term of conception of product and process, using biological raw materials.

Plan of the course:

  1. 1) Historic of environmental management
  2. 2) Evolution of the management of companies and public policy
  3. 3) Methods of flows quantification of matter and energy (MEFA)
  4. 4) Environmental and economic analysis of life cycle (EELCA)

General objectives :

In a data driven world, traditional charts and usual means of visualization are now out of fashion. Data is the new soil and the the new oil. Professionals are being required to support their case and make datadriven decisions. Non-IT professionals must now more than ever being able to produce and comprehend clear insights from wide datasets and communicate results effectively

Plan of the course:

  1. 1. What is “Data Visualization”?
  2. 2. Stories behind the numbers
  3. 3. Harvest and transform your data
  4. 4. Tools of the trade
  5. 5. How to visualize
  6. 6. Practical work

General objectives :

In a data driven world, non-IT professionals are overwhelmed with data though constantly looking for structured insights and knowledge. They are then asked to contribute to software development project, from inception phase, requirements elicitation up to data model design and even data management process definition. They are challenged beyond Microsoft Excel and simple end-users means of data management. Students must be able to address such data issues.

Plan of the course:

  • 1. Data vs information vs knowledge
  • 2. What is a database
  • 3. Conceptual modeling
  • 4. Logical modelling
  • 5. Physical modelling
  • 6. SQL
  • 7. Practical works

General objectives :

To complete the initiation to Biostatistics using a practical and illustrated approach of typical data analysis problem in Biotechnology.

Plan of the course:

  • 1) The data
  • 2) Data description
  • 3) Modelisation and statistical hypothesis testings
  • 4) Epidemiology : Study design and measurement of association between exposure and disease status
  • 5) Analysis of binary trait: Sensibility, Specificity, ROC
  • 6) Non parametric tests
  • 7) Guidelines to build a medical questionnary

General objectives :

Bring a global vision of recent developments in industrial biotechnologies with a focus on energy, chemistry and agroindustries. Highlight recent industrial realizations selected in different regions (Europe, North America, Asia) and from different typologies of industries (startup companies to large multinationals).

Plan of the course:

  • General introduction to bioprocesses and biotechnologies
    1. 1. Bioprocesses for new sources of energy
    2. 2. Introduction to bio-based chemical compounds
    3. 3. Biotechnology tools for agro-food industries
    4. 4. Biotechnology based development and production of food & nutraceutical molecules
    5. 5. New developments in fragrances and ingredients for the cosmetic industry

General objectives :

Manage in team an innovative project linked to biotechnological issues. Be able to follow its proof of concept after Biotech4.

Management

General objectives :

Understand the science of manipulation based on the scientific publications. Learn one new tool in competitive intelligence, the strategic chess and two new methods to gather information. The first is applied on trade shows, and the second on online influence operations.

Plan of the course:

  • 1. Introduction
  • 2. The strategic chess : Detection and information risk management
  • 3. The art and science of influence
  • 4. Trade show intelligence
  • 5. Influence operation

General objectives :

This course is designed to develop an understanding of the good practices and issues found when working in a group setting in a global environment.

Plan of the course:

Principles of good leadership Cross-cultural communications Conflict resolution

General objectives :

To focus on some specific knowledge to better understand the big environmental issues, to bring up to date information and data to follow the evolutions, to build a personal and critical opinion.

Plan of the course:

  • 1) A growing population, with a modern way of life, facing the scarcity of natural resources
  • 2) Alarming pollution leading to frightening climate changes, biodiversity loss, deforestation, marine disasters
  • 3) An international awareness: Achievements and disappointments International conferences (Kyoto, Cancun, Nagoya, Rio…). The national policies led by the big polluters (the historical agreement between China and the USA), the expectancies of developing countries
  • 4) Sustainable development: an undeniable priority for industry and agriculture. The beginning of a new area in business, a new and profitable impulse

General objectives :

Familiarize with a comprehension of the general environment of corporate financing. Focus on private equity as it is one of the main financing sources for (i) unquoted companies, and (ii) the creation and first steps of IT companies

Plan of the course:

  1. 1. The current global context
  2. 2. Overview of corporate financing sources
  3. 3. Private equity
  4. 4. Entrepreneurs and private equity – Case study

MAJOR Research and Development

General objectives :

Be able to reproduce a scientific protocol in our laboratory Apply what has been learnt in the classroom or practical work of the Bachelor Cycle to real laboratory situations.

General objectives :

  • Propose a precise research project that starts from this article and goes beyond, in any direction the group chooses, from fundamental to applied research.
  • Justify the project and demonstrate its feasibility on the basis of the article and possibly related ones.
  • Apply it in order to obtain preliminary evidence supporting the project.

General objectives :

To explore in detail the main techniques, other than sequencing methods, available to analyze the complexity of the genome. Furthermore that course will allow students to set up methods with techniques accurate to evaluate and /or measure genomic expression. Finally, understand how automation will help all fields of health in the management of samples

Plan of the course:

  1. I. Genome analysis
  2. II. Transcriptomic : gene expression
  3. III. Robotic
    1. 1: introduction to robotic
    2. 2: instrumental consideration in the field of research
    3. 3: options and devices for integrated systems

General objectives :

This course is designed to equip students with basic but very important molecular & structural bioinformatics methods, focusing on key technologies to solve various problems they may encounter in their further research and/or industrial practice. The module material is applicable to macromolecules of special interest in biotechnology & medicine (e.g. fluorescent proteins, therapeutic antibodies…). A set of exercises has been specifically designed in such a way that the students could directly observe most of the concepts presented in the theoretical sessions. The aim is for the students to get insight in and use modern structural bioinformatics methods

General objectives :

Have basic knowledge in virology and learn to use the cellular and molecular tools to develop research strategies in viral pathogenesis.

Plan:

  • a) Distribution students to relevant recent publications (EBV, Ebola, lyssavirus, prion, papillomavirus)
  • b) Overview of the virus: protein structure, organization genomics and cell tropism (courses)
  • c) Neurotropic viral persistence: the model of lyssavirus (courses) / Role of matrix protein in virusinduced apoptosis
  • d) Pathophysiology of Epstein-Barr virus (presentation) / MicroRNA produced by EBV and cell survival
  • e) Pathophysiology of papillomavirus (presentation) / Rôle PV-E6 protein in cell transformation
  • f) Pathophysiology of Ebola virus (presentation) / PI3kinase signaling and control of viral entry
  • g) Pathogenesis of prion diseases (presentation) / Anti-prion gene / Therapy: use of dominant-negative vectors

General objectives :

The main objective of this course is to sensitize the auditors to the statutory environment governing use of animal models in scientific projects.

Plan:

  1. 1. Introduction to functional exploration
  2. 2. Implementation of the current regulations
  3. 3. Implementation of a protocol according to a defined research program
  4. 4. Case practises (DAPAFIS)

MAJOR MARKETING & PRODUCT DEVELOPMENT

General objectives :

Be able to reproduce a scientific marketing approach on an innovative existing product Apply what has been learnt in the classroom of the Marketing Major.

General objectives :

Build a price policy that will be accepted from the market and profitable for the company, and make it customer-understandable. Negotiate that price facing the company environment and competition influence. Master price negotiation techniques. This course should enable students to know the price components and allow them to determine the desirable price of a product and/or service. This course will also offer the acquisition and training of trading methods related to price and value creation.

Plan:

At the end of the course, students must develop an understanding the different tools related to the transactions and are able to:

  1. 1. Evaluate customer value and customer lifetime value,
  2. 2. Know and use the different pricing methods
  3. 3. Integrate pricing in management range
  4. 4. Know and evaluate the visible and hidden components of the price of a product or service
  5. 5. Use Porter's value chain to determine the competitive advantage and price positioning
  6. 6. Evaluate the different notions of value
  7. 7. Determine the client's value chain and measure the created value
  8. 8. Methodically prepare the terms of a negotiation
  9. 9. Negotiate and defend the price and the value of a service, product or offer in different business situations and master the different stages of a win-win negotiation

General objectives :

  • Learn about the specific characteristics of B to B Marketing regarding products and services sales and business between professional organisations;
  • Manage and master marketing tools, including specific BtoB tools;
  • Include and master strategic thinking and build an overview about marketing tools in strategic BtoB;
  • Master a general overview of methods, concept and tools in marketing.

Plan:

Different courses and workshops:

  1. 1. The specifics of B to B marketing
  2. 2. Field; Segmentation; Actors
  3. 3. Market research in B-to-B
  4. 4. Marketing services
  5. 5. Loyalty tools
  6. 6. Marketing business creation
  7. 7. Purchasing processes and decision making in B to B
  8. 8. Communication in B to B

General objectives :

To move from your initial project idea linked to one or more of the thematic windows to a full project proposal, important planning and analyzing tasks described

Plan:

  • Find a Project
  • The product in the market national and international
  • International negotiation and geopolitical influence in international project implantation
  • Innovation and sustainable development
  • Ethic and business

General objectives :

To lead students to be autonomous in the evaluation of a situation, to be able to choose, adapt and built tools to make the right decisions regarding salesforces, distribution and packaging.

Plan:

  • Preliminary module: Packaging, needs and functions
  • Module 1: Packaging, brand and design
  • Module 2: Ecology and packaging
  • Module 3: The distribution channels
  • Module 4: The marketing plan
  • Module 5: Sell to the salesman
  • Module 6: The strategy and the marketing mix

General objectives :

Acquire the basic knowledge to conceive of, develop and present a marketing strategy for a product.

Plan:

Using a combination of class presentations, exercises and a marketing plan simulation, the students will:

  1. 1. Establish the qualities of a specific product,
  2. 2. Determine its use, general and/or specific,
  3. 3. Analyze the problems and potential opportunities associated with the sale of the product,
  4. 4. Determine the market positioning of the product
  5. 5. Determine the public to whom the product should be targeted
  6. 6. Create, design, develop and execute a strategy to introduce a specific product on the market
  7. 7. Examine and use imposed budget limitations in the development of an effective marketing strategy
  8. 8. Present and explain the strategy developed from the simulation to “the customers” who requested this strategy

Bioproduction and Quality

General objectives :

To adequately ensure that the student achieves the learning objectives of the production major, it is important to test the knowledge and skills acquisition. Accordingly, the project is based on a deep analysis of an Operation, a Supply Chain or a process in a company setting in order to assess whether students are capable of applying what has been learnt in the classroom to real-world situations. Groups will be 5 to 6 students in size on average. Sup’Biotech seeks also to promote closer working relationship with private companies to high-quality research and outstanding academic programs

Plan:

Three different subjects have been proposed to our students this year. The third one is a collaboration with a private company.

  • Subject 1: CONCEPTUALISATION AND MANAGEMENT OF A PRODUCTION LINE
  • Subject 2: EXPERIMENTAL KITCHEN RENOVATION
  • Subject 3: INDUSTIALIZATION OF A WHEAT PEPTONE PROCESS

General objectives :

Get general knowledge baseline in Quality Assurance principles and application in Industrial project environment.

Plan:

  1. 1. Regulation overview
  2. 2. Quality Management
  3. 3. Risk Assessment & Management
  4. 4. Quality by design
  5. 5. Certification, Audit, Compliance

General objectives :

The aim of this course is to engage students in active discovery of risk management principles, included in risks hazards and technological risks. These lessons are a basic approach for students who will evolve in a complex professional environment. At the end of the courses, the students will be able to evaluate risks in its different category and thus improve performance for their future companies.

Plan:

  1. 1. Introduction to Risk Management
  2. 2. Risk Management concepts and methods
  3. 3. The risks in the law + Natural risks
  4. 4. Industrials and Biotech risks
  5. 5. Presentation of cindyniques

General objectives :

Application of Six Sigma tools and change methodology for highly regulated environments

Plan:

  • I. Six Sigma
    1. 1. Six sigma, a tool of performance
    2. 2. The concepts of Six Sigma
    3. 3. Six Sigma Management
  • II. cGMP’s
    1. 1. Commissioning, Qualification & Validation
    2. 2. Validation Processes for GMP Facilities and Systems
    3. 3. The ASTM E2500-7

General objectives :

Lean management as:

  • A way to see, and work on, operational processes
  • An approach to develop the operational performance
  • A lean perspective on managing teams and projects

Plan:

  1. I. Introduction to lean : origins, process and flow
  2. II. Value stream mapping
  3. III. 7 Wastes
  4. IV. Project description and management using A3s
  5. V. Methodologies for improvement
  6. VI. Lean management
  7. VII. Lean product and process development
  8. VIII. Total Productive Maintenance

MINOR FOOD SCIENCES AND TECHNOLOGIES

General objectives :

Students will be introduced to food safety and food preservation science. Students will gain an understanding of the principles and science behind foodborne illnesses and food preservation methods. They will learn how to apply these principles to safely preserve food by traditional and emerging methods.

Plan:

  1. I. Food risks
    1. 1. Food risks from microbial origins
    2. 2. Food risks from chemicals
    3. 3. Control of risks
  2. II. Food preservation
    1. 1. Traditional Preservation Technologies
      1. 1.1. Using Preservatives
      2. 1.2. Removing water
      3. 1.3. Lowering temperature
      4. 1.4. increasing temperature
    2. 2. Emerging Preservation Techniques
    3. 3. Packaging

General objectives :

This course has been designed to help our students understand the process of developing and marketing a new product. There are five phases to developing and marketing a new product. Known as the 5D’s, they are Decide, Discover, Define, Develop and Deploy. However, within each phase there are many different steps.

General objectives :

This course has been designed to help our students understand the process of developing and marketing a new product. There are five phases to developing and marketing a new product. Known as the 5D’s, they are Decide, Discover, Define, Develop and Deploy. However, within each phase there are many different steps.

Plan:

Cours

  1. 1. Utilisation de l’analyse sensorielle
  2. 2. Ensemble des Normes Afnor relatives à l’analyse sensorielle
  3. 3. Définitions et utilisation (tests) des Normes relatives à l’olfaction et la gustation
  4. 4. Arôme (définition des matières premières et de leur difficulté d’utilisation …)
  5. 5. Législation et contrôle analytique de la Législation

Travaux pratiques

  1. 1. Comparaison sur des produits type gâteaux, chocolats et bonbons (seuls autorisés pour garder Les règles d’hygiène et de sécurité)
  2. 2. Cartographie de comparaison

MINOR COSMETOLOGY

General objectives :

The principal objective is to improve students’ knowledge in skin biology and cosmetic actives for the cosmetic part. For the pharmaceutical purpose the objective is to present the new therapies based on cell therapies.

Plan:

The different presentations consisted in:

  • Skin biology
  • Biologic tools used in cosmetology
  • Skin substitutes
  • Cosmetic Actives (anti-ageing, slimming products…)
  • Skin ageing
  • Sun and skin
  • Innovative cell therapies

General objectives :

The goal is to know the main requirements for the formulation of a cosmetic product From design to marketing (with the file on mandatory European Portal since July 2013) according to the country where it is to be marketed.

Plan:

  1. 1. Legislation: Historic until July 2013
  2. 2. Product Dossier
  3. 3. Chemical raw materials family
  4. 4. Finished products by type
  5. 5. Scientists - Methods required by European legislation to control products
  6. 6. The skin and hair

General objectives :

  • Understand the use of sensory analysis
  • Internal and test consumer
  • For advertising, marketing

Plan:

  • Our 5 senses
  • According to the AFNOR Standards
  • Mandatory vocabulary odour, texture
  • Test types: binary, duo-trio, triangle
  • Statistical tests
  • Various experts
  • Discriminative tests, hedonic
  • Preference Mapping
  • Establishment of a panel on two cosmetic creams according to the Standard of May 2012

General objectives :

Based on raw materials, this practical work is oriented to manage formulation of product, and respect quality of the product.

MINOR ENVIRONEMENT

General objectives :

Gain skills to assess environmental risks induced by chemical pollutants either in the frame of observed pollution or to prevent them, propose method to limit them. Understand interactions between science and environmental regulations.

Plan:

  1. 1. Study of chemical pollutants in environment through a bibliographical work
  2. 2. Case study based on the assessment of an insecticide dossier submitted in a regulatory framework (BPR, Regulation (EU) 528/2012)
  3. 3. Practical laboratory case : assessment of the feasibility of an ecotoxicity test dealing with the toxicity of a chemical on micro-organisms from a sewage treatment plant.

General objectives :

  1. 1) Acquire knowledge on different aspects of environmental pollution: pollutants, dynamics, effects, risk and remedies.
  2. 2) Understanding of appropriate remediation technologies using organisms (bacteria, fungi and plants) on polluted environments: water, soil and air.

Plan:

  1. 1. Soil Pollution
  2. 2. Water Pollution
  3. 3. Air pollution
  4. 4. Atmospheric sampling
  5. 5. Microbial biodegradation
  6. 6. Mycoremediation
  7. 7. Pollution remedies
  8. 8. Phytoremediation
  9. 9. Pollution / Methods applied in bioremediation. Student's lectures

General objectives :

Based on bioremediation and detection of pollutants, this practical work is oriented to manage the technics of detection of pollutants (detection, separation...)

MINOR HEALTH AND PHARMACY

General objectives :

Understanding the fundamental biological mechanisms of angiogenesis. Knowing the preclinical and clinical fields of application.

Plan:

This course is based on students’ oral presentations. Scientific publications are given to the students. Students have to read, understand, analyze and present their publication as if they were given a lecture. Other students are randomly chosen to ask questions during the lecture.

General objectives :

The goal of this teaching is to introduce the various techniques of gene therapy and genome surgery, with a special focus on virus assisted techniques.

Plan:

  1. 1/ Definition of gene therapy
  2. 2/ What are the best candidate diseases for gene therapy?
  3. 3/ How to make a vector from a virus ?
  4. 4/ The viral vector must bypass limitations due to tropism and cell-specific restriction and allow for regulated expression of the transgene
  5. 5/ Specific cases
  6. 6/ Gene therapy tomorrow

General objectives :

Acquisition of the basic information needed to work in a field related directly or indirectly to neurology: neuron concepts, nervous system, neural information, major neural pathologies. Analyze the status of a scientific question in neurobiology and its challenges by providing a collaborative work from the literature.

Plan:

  1. 1. The neuron.
  2. 2. Where are and where will be the neurons?
  3. 3. How are tasks distributed in the nervous system?
  4. 4. Which centers organize neural functions above?

General objectives :

Apprehend the different steps of the molecular innovation Understand the key factors in the conception of an innovative product Understand the role and sometimes the risk for the patient of the innovation.

Plan:

Based on sequential conferences by different actors of the health sector.

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