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Programme 4e année du cycle Graduate

Fundamental learning and entrepreurship

General objectives of education

Mastering communication techniques to be understood more quickly, without misinterpretation

Detailed course structure

Spend less time writing
  • The conditions to write.
  • Solve the problem of the white page permanently by the blind method.
  • Bring up a plan based on the ideas
Learn to convince the reader
  • How to convey an important message quickly
  • Taking care of the reader to better convince the
  • Pay attention to readers (exercise)
  • The argumentation methods
  • The readers are lazy: the principle of the law of least effort
  • Lying: use the principles of perversely writing to pervert reality
  • Run some selected ideas
  • Respect the reading mechanisms
  • Place the important words in the right place to increase the impact
  • Linearity of reading and logic to be followed in a paragraph
  • The consistency between the titles and text
  • Bringing added value by focusing on the difference
  • Structure: articulate your phrases and ideas
  • The formulations and words to avoid
  • Make an introduction and a conclusion (what is it actually an introduction?)
  • Choose words (+ exercise)
  • To increase the impact of his writings: the layout.

General objectives of education

The overall objective of the course is to fully grasp the existence and impact of cultural differences through discussion guides based on the main theoretical tools as well as many examples. The purpose of this training is to open students’ mind to embrace differences between cultures and to teach them not to judge each other by their own cultural rules, but rather to try to understand and to develop an attitude of tolerance. It is an excellent introduction to intercultural communication for any person required to grow professionally abroad

Detailed course structure

  1. A)Theory
    • I. To understand each other above all else
    • II. How do we communicate within a culture? Communication problems between people of different cultures
    • III. Negotiation and culture
    • IV. Conclusion
  2. B) Application via case studies

General objectives of education

Understand the science of manipulation based on the scientific publications. Learn one new tool in competitive intelligence, the strategic chess and two new methods to gather information. The first is applied on trade shows, and the second on online influence operations.

Detailed course structure

  1. 1. Introduction
  2. 2. The strategic chess: Detection and information risk management
  3. 3. The art and science of influence
  4. 4. Trade show intelligence
  5. 5. Influence operation

General objectives of education

The course "Business Strategy" aims to give students an overview of the business strategy but also and especially to provide relevant reflection methodology to identify the key factors affecting the development of the company

Detailed course structure

  1. 1. The structure of a multi-product company
    • Strategic segmentation of companies
    • Analysis of the customers’ needs
  2. 2. Environmental Analysis
    • Industries’ limits
    • Strategic segmentation industries
    • Geographic Classification of industries
    • Industry Maturity
    • Competitive typology
    • The model of Porter
    • The Ansoff Matrix Internal
  3. 3. Analysis
    • Competitive advantage: creating value: price war and differentiation strategies (Act of experience, Volume Effects)
    • The strategic moves
    • The Ansoff Matrix
  4. 4. The value creation
  5. 5. The Effectuation methodology and MVP
  6. 6. The business model canvas

General objectives of education

Master the legal bases of Industrial Property

Detailed course structure

  1. 1 – Introduction
  2. 2 - Not Inventions
  3. 3 - Exceptions to patentability
  4. 4 - Living Patentability
  5. 5 - The issues
  6. 6 - Patentability criteria
  7. 7 - Protect an invention

BIOLOGICAL ENGINEERING

General objectives of education

Understanding the pharmacokinetics and pharmacodynamics; identifying the drugs’ mechanisms of action.

Detailed course structure

This course is based on the professor lecture. Exercises with practical cases are done during the class.

General objectives of education

Understand the toxicants’ mechanisms of action. Know how to assess toxicology today.

Detailed course structure

This course is based on students’ oral presentations. Scientific publications are given to the students. Students have to read, understand, and present their publication as if they were given a lecture.

General objectives of education

The main objective of this course is to give the current models of synthetic and cellular membranes, applied to biotechnologies like in drug delivery

General objectives of education

Understand :

  • The definition of medications (pharmaceutical & biotechnology) and medical devices (including e-health), their environment (market, governments’ healthcare policies, role of healthcare authorities)
  • The product life-cycle (medications and medical devices) from development to commercialisation, including registration and market-access.
  • The stakeholders of the Healthcare industry, their business-models, their challenges & opportunities and business-development strategies
  • Objectives, design and execution of the Strategic and Tactical Marketing Plan

Detailed course structure

  1. 1. Overview of the Healthcare Industry
  2. 2. Pharmaceutical and biotechnology medications
  3. 3. Medical devices
  4. 4. Challenges faced by the Healthcare Industry
  5. 5. Opportunities for the healthcare Industry
  6. 6. The Strategic and Tactical Marketing Plan
  7. 7. Healthcare companies’ organisation
  8. 8. Industry’s customers
  9. 9. Business-case

General objectives of education

Introduction of genetic engineering concepts acquired during the first cycle

Detailed course structure

  1. 1) 3D visualization of nucleic acids [Jmol]
  2. 2) Using of genetic databases [UCSC, Genecards, OMIM, NCBI…]
  3. 3) Using an editing tool sequence [APE]
  4. 4) Sequencing Read Data [APE]
  5. 5) Design of primers [PRIMER3]
  6. 6) Design of RNAi [DSir]
  7. 7) Writing an experimental protoco

ENGINEERING SCIENCES

General objectives of education

Develop students’ sensitivity so they will be able to choose for a given analysis the best technique on the basis of cost, information needed, precision required, number of samples to analyse, amount of sample, potential interferences to the measures, etc

Detailed course structure

  1. 1. General aspects of analytical physical chemistry
  2. 2. Mass spectrometry
  3. 3. Analysis of post-translational modifications of proteins

General objectives of education

This course aims to give the students a general and qualitative view of fluid dynamics. After a general description, the focus is put on microfluidics situations which are relevant for flows of biological fluids (in medical analyses or blood circulation, for instance).

Detailed course structure

  1. 1. General Introduction to fluid dynamics
  2. 2. Navier-Stockes equation, laminar and turbulent flows, Reynolds number
  3. 3. Poiseuille flow in circular pipe, applications to blood circulation
  4. 4. Blood rheology, non-newtonian rheology of complex fluids. In this last part, the course is supported by showing some fluids with spectacular properties.

General objectives of education

Give skills to student to call the best engineering skills or principles to solve a problem, considering the technical, economical and project management aspects of a sustainable solution.

Detailed course structure

  1. A/ Classification of biological, ecological and environmental engineering
    1. 1. Un-sustainability and Sustainability of the economy and human life: ecological economy
    2. 2. From Science, Philosophy, Policy-making, Markets to Engineering
    3. 3. Scales and natural-domesticated-artificial systems: an operational classification
  2. B/ Principles and engineering positioning between science and politics
    1. 1. A tour in the Engineering world to day : best practices
    2. 2. What is the scientific and epistemological basis of the identified engineering?
    3. 3. Focus on the main engineering areas: biological-ecological principles and materials, applications, costs and impacts
    4. 4. Which engineering for which main goals of the sustainable transition of the economy?

General objectives of education

Train students in the analysis of complex molecular structures, their decomposition into simple structures and the assembly of these structures

Detailed course structure

  1. 1. The art of organic synthesis: background and issues
  2. 2. Analysis retro synthetic: Definitions
  3. 3. The different types of disconnections
  4. 4. Some cases of coupling reactions with transition metals
  5. 5. Some examples of industrial syntheses optimization

General objectives of education

Modeling the chemistry of life and predicting biological function. Why Structural Bioinformatics? Generally speaking, the function of a protein is determined by its threedimensional structure, and therefore structural information is crucial for understanding the working of proteins. However, experiments, prediction and simulation of protein structures remain difficult. This course will provide you with an overview of existing computational techniques, to validate, simulate, predict and analyze protein structures. More importantly, it should provide practical knowledge about how and when to use such techniques.

Detailed course structure

  1. 1. Structural bioinformatics: a historical perspective
  2. 2. The revolution of genomics and computational biology: era of structural genomics (protein structure sources, experimental methods)
  3. 3. Anatomy of a protein and macromolecular constituents, energetics
  4. 4. Secondary structure prediction
  5. 5. Protein structure classification: elements of topology and folding
  6. 6. Multiple sequence alignment
  7. 7. Molecular phylogeny and evolution
  8. 8. Tertiary structure prediction: protein fold prediction, comparative modeling and structure evaluation
  9. 9. Molecular mechanics and dynamics: simulations of movements and drug-target interaction
  10. 10. Basics of cheminformatics, docking experiments.

General objectives of education

Close the training in students statistics through a comprehensive practical and illustrated experiential learning and practice of statistics in biomedicine

Detailed course structure

  1. 1. A global overview of the statistics in Use- From raw data to p-values
  2. 2. Statistics in Biomedicine
  3. 3. Statistics in Biomedicine and biotechnology

General objectives of education

The objective of the module is to teach our students to analyze and design processes and to provide them a solid foundation in basic engineering principles, while allowing specialization in environmental engineering, biochemical/biomedical engineering, food engineering, process control…

Detailed course structure

  1. 1. Introduction
  2. 2. Transformation units and dimensions
  3. 3. Heat transfer
  4. 4. Drying

Prerequisites:

  • Data visualization
  • Database design
  • Programming proficiency in Java, Python or R.

General objectives of education

Data is the new soil. Research and marketing and operations are constantly challenged and transformed by data driven discovery and machine learning-based prediction. Skills required to lead and conduct data analytics at a massive and complex levels - scalable data management on and off the cloud, data modelling, statistical modelling, data mining algorithms, tools proficiency – span a wide range of theoretical and technological disciplines. Students have to be able to be part of and contribute to this data revolution.

Detailed course structure

  1. 1. Introduction
  2. 2. What is Data Mining?
  3. 3. Data Mining and Ethics
  4. 4. A Data Mining Process
  5. 5. Data Mining techniques
  6. 6. Data Mining tools

General objectives of education

Manage in team an innovative project linked to biotechnological issues. Be able to bring a proof of concept of the project

Major research and development

General objectives of education

Be able to reproduce a scientific protocol in our laboratory Apply what has been learnt in the classroom or practical work of the Bachelor Cycle to real laboratory situations.

General objectives of education

Master the tools necessary to understand the field of stem cells and their applications, and some aspects of regenerative medicine.

Detailed course structure

  1. 1. Differentiation
  2. 2. Asymmetric division
  3. 3. Pluripotency / pluripotency
  4. 4. Transgenesis
  5. 5. Cell and gene therapy

General objectives of education

To explore in detail the main techniques, other than sequencing methods, available to analyze the complexity of the genome. Furthermore that course will allow students to set up methods with techniques accurate to evaluate and /or measure genomic expression. Finally, understand how automation will help all fields of health in the management of samples

Detailed course structure

  1. 1) The organization of DNA : DNA polymorphism et genetic variation
  2. 2) Fragment analysis and disease
  3. 3) Introduction to STR
  4. 4) Introduction to MLVA
  5. 5) Introduction to AFLP
  6. 6) Introduction to SNP
  7. 7) Introduction au TILLING
  8. 8) Introduction to genetic quantitation
  9. 9) DNA methylation studies
  10. 10) Introduction to LOH and MSI

General objectives of education

Apprehend the notion of regulation in R & D Learn useful vocabulary

Detailed course structure

  1. 1) Introduction to law and regulations for R&D
  2. 2) Standards treaties / ISO / industry agreements
  3. 3) Administrative law : FDA, USDA, EFDA
  4. 4) Intellectual property : types of patents, patentable inventions, patentability criteria

Prerequisites:

Know the molecular carriers for heredity and the classical techniques for studying them

General objectives of education

Present the major changes in hereditary information and their mechanisms of occurrence or transmission, their monogenic or multifactorial pathological consequences and their study methods

Detailed course structure

  1. 1. What is the support for genetic information and how does it express itself? Molecular bases of human genetics
  2. 2. What can we learn from a family history? The place of genes and genetics in individuals’ relations: between identity and polymorphism
  3. 3. What are the different variations of the genome, where do they originate from and what are their consequences? Classification, origin and consequences of genome’s variations
  4. 4. How can patients’ chromosomes be studied? Cytogenetics
  5. 5. How can we check a patient’s DNA for gene mutation? Gene testing in individuals and population
  6. 6. How to deal with multifactorial diseases? Multifactorial diseases: a nightmare for the geneticist / investigating the genetics of complex diseases
  7. 7. What is epigenetics? Epigenetics: origin and consequences
  8. 8. How was/is the human genome sequenced and mapped? Unraveling the human genome
  9. 9. What can genetics do about genetic diseases? New approaches to treating diseases (some examples)
  10. 10. Is genetics ethic? Ethical issues raised by the knowledge and techniques in genetics

Marketing and product management

General objectives of education

Be able to reproduce a scientific marketing approach on an innovative existing product Apply what has been learnt in the classroom of the Marketing Major.

General objectives of education

The course "Business Strategy" aims to give students an overview of the business strategy but also and especially to provide relevant reflection methodology to identify the key factors affecting the development of the company.

Detailed course structure

  • The structure of a multi-product company
  • Environmental Analysis
  • Internal Analysis
  • The value creation
  • The Effectuation methodology and MVP
  • The business model canevas

General objectives of education

Learn about the specific characteristics of B to B Marketing regarding products and services sales and business between professional organisations; Manage and master marketing tools, including specific BtoB tools; Include and master strategic thinking and build an overview about marketing tools in strategic BtoB. Master a general overview of methods, concept and tools in marketing

Detailed course structure

  1. 1. The specifics of B to B marketing
  2. 2. Field; Segmentation; Actors
  3. 3. Market research in B-to-B
  4. 4. Marketing services
  5. 5. Loyalty tools
  6. 6. Marketing business creation
  7. 7. Purchasing processes and decision making in B to B
  8. 8. Communication in B to B

General objectives of education

To be able to play an active part in an innovation process and to be able to choose, to use and to adapt basic tools in this domain.

Detailed course structure

  1. I. Definition and reason why
    1. 1. The need for innovation
    2. 2. Definition of innovation
    3. 3. The consumer and innovation
  2. II. The process
    1. 1. Objectives and types of processes
    2. 2. The climbing commitment
    3. 3. The 6 parts
  3. III. Functional specifications
    1. 1. The role of functional specifications
    2. 2. Four main parts
    3. 3. Tools
  4. IV. The business model
    1. 1. Why talking about it
    2. 2. A tool : the business model canvas

General objectives of education

Develop their effectiveness during a face trade deal

Detailed course structure

  • Prepare your visit
  • The key steps of the interview
  • Needs survey & reformulation
  • The presentation "commercial" of a product
  • Customize its presentation to the typology of the interlocutor
  • Be comfortable with objections
  • Dare to conclude his visit and program monitoring
  • Alternating knowledge inputs and scenarios

Major bioproduction and quality

General objectives of education

To adequately ensure that the student achieves the learning objectives of the production major, it is important to test the knowledge and skills acquisition. Accordingly, the project is based on a deep analysis of an Operation, a Supply Chain or a process in a company setting in order to assess whether students are capable of applying what has been learnt in the classroom to real-world situations. Groups will be 5 to 6 students in size on average. Sup’Biotech seeks also to promote closer working relationship with private companies to high-quality research and outstanding academic programs.

General objectives of education

The objective of the module is to give to participants a general view of Operations and Supply Chain Management (OSCM) theories, current practices and major trends. It will cover the strategic, tactical and operational levels of the supply chain. The course emphasizes on applications by using problem situations, so that students may apply their acquired knowledge to real business problems, and work better with people from other functional areas of the firm

Detailed course structure

  • Total Quality Management
  • Just-In-Time and Lean manufacturing concepts
  • Relating logistics performance to business performance, in particular the achievement of marketing objectives through achievement of customer service levels
  • Capacity Planning
  • Inventory management
  • Purchasing processes
  • Storage and warehousing methods
  • Transport and related issues such as choice of mode and routing
  • Location of facilities such as warehouses

General objectives of education

The objective of the module is to give to participants a general view of the Good Manufacturing Practice for Food industry, Drug and medical Devices. The course includes the reading of the regulation texts as provided by the US Food & Drug Administration.

Detailed course structure

  1. 1. Food industry and restaurants
  2. 2. Drug and Pharmaceutical industry
  3. 3. Medical Devices

Other related topics such as Air Quality measurement, Quality by design, Sanitary security administrations are discussed.

General objectives of education

This course presents a comprehensive review of the approach and tools of scale up, and the observation of concrete case studies.

Detailed course structure

  1. 1. Definitions
  2. 2. Product Development
  3. 3. Regulatory
  4. 4. Limits of scale up
  5. 5. Possible Problems

Minor food sciences and technologies

General objectives of education

The general purpose of this course is to raise students’ awareness about the innovation approach among food industry

Detailed course structure

  1. 1. How to characterize innovation: definitions
  2. 2. 5 principles to understand what innovation is
  3. 3. How innovation boosts the market
  4. 4. Risk and innovation
  5. 5. Developing a new product
  6. 6. Business growth and innovation
  7. 7. Introduction to the “blue ocean” strategy
  8. 8. Food industry: how judging the innovative nature of a food product
  9. 9. An example of food innovation: retailers’ private labels

General objectives of education

Have a basic knowledge of the major ingredients used in the food industry and their impact on the final products’ characteristics.

Detailed course structure

  1. 1. Oils & Fat
  2. 2. Candies
  3. 3. Polyols
  4. 4. Dressings
  5. 5. Light dressings
  6. 6. Hydrocolloids
  7. 7. Native Starches
  8. 8. Chemical modification
  9. 9. Physical modification
  10. 10. Raw materials
  11. 11. Production processes

General objectives of education

This course provides an overview of the functions of carbohydrates, protein, fats, energy, and the major vitamins and minerals that are determinants of health and diseases in human populations

Detailed course structure

  1. 1. Introduction to nutrition
  2. 2. Factors influencing food selection
  3. 3. Nutrients
  4. 4. Basic nutrition concepts
  5. 5. Nutrient recommendations

General objectives of education

Based on nutrition and raw materials, this practical work is oriented to manage formulation of product, and respect quality of the product

Minor cosmetology

General objectives of education

The main objective of this course is to give the basic knowledge necessary in order to :

  • Be able to develop a cosmetic product from the idea to the launch on the market
  • Be involved in its development

Detailed course structure

  1. 1. The skin morphology and structure
  2. 2. Skin and cosmetics
  3. 3. Cosmetics formulation basics
  4. 4. Development of a product : the different steps from idea to market
  5. 5. Cosmetic evaluation

General objectives of education

  • To know the different cosmetic formulas
  • To know the general regulation of cosmetic raw materials
  • To know the different classes of cosmetic raw materials
  • To be able to choose a raw material in a specific class

Detailed course structure

  1. 1. Different cosmetic formulas
  2. 2. General regulation of the raw materials : positive list, negative list
  3. 3. Hydrophilic raw materials
  4. 4. Lipophilic raw materials
  5. 5. Preservatives
  6. 6. Surfactants
  7. 7. Colouring raw materials
  8. 8. Powders
  9. 9. Silicons
  10. 10. Examples of labelling

General objectives of education

Based on raw materials, this practical work is oriented to manage formulation of product, and respect quality of the product

Minor environment

General objectives of education

Understanding of the soil microbial habitat and microbial relationships with water, atmosphere and plants in order to comprehend how this microscopic life in soil influences virtually everything in our lives from the water we drink, the food we eat, to the biogeological cycles.

Detailed course structure

  1. 1. Bio-geo interactions
  2. 2. The environmental cycle of water
  3. 3. Soil microbe-plant-relationships
  4. 4. Soil biological quality
  5. 5. Soil microbial assessing methods
  6. 6. Microbes on earth/Biogeochemical cycling
  7. 7. Biotechnology associated to soil microbiology
  8. 8. Practice Work: Soil respiration test

General objectives of education

Based on raw materials, this practical work is oriented to manage formulation of product, and respect quality of the product

General objectives of education

Understand biotechnology contributions, requirements and opportunities within the waste management business

Detailed course structure

  1. 1. Positioning of the main key concerns related to Environment issues
  2. 2. Reminders and basic knowledge related to waste management
  3. 3. Focus on biological treatment routes
  4. 4. Contaminated soils bioremediation
  5. 5. Contributions of biotechnology processes to Biofuels production and CO2 conversion into biomass
  6. 6. Case applicative exercise

General objectives of education

  • Become familiar with theories and concepts used in marine ecology.
  • Better understand main problematic and challenges in marine ecology

>Detailed course structure

  1. 1. Elements of marine biology and ecology
  2. 2. Marine ecosystems disturbance and their consequences

Minor Health and pharmacy

General objectives of education

Identifiying the potential roles of oligonucleotides as tools for target validation and therapeutic strategies.

Detailed course structure

This course is based on students’ oral presentations. Scientific publications are given to the students. Students have to read, understand, analyze and present their publication as if they were given a lecture. Other students are randomly chosen to ask questions during the lecture.

General objectives of education

Master the control optimization strategies of biological and physicochemical properties of bioactive molecules, in the context of drug discovery

Detailed course structure

  1. 1. Introduction : structure activity relation SAR
  2. 2. Design and optimization of biological molecules : hit to lead
  3. 3. Lead optimisation :in vitro to in vivo
  4. 4. Metabolization
  5. 5. Lipinski rules
  6. 6. Strategy of drug repositioning
  7. 7. Examples of biological optimization

General objectives of education

Control approaches to biotechnology in drug development

Detailed course structure

  1. 1. Development phases of a medicament
  2. 2. A time of change
  3. 3. Identification of new candidates
  4. 4. Attrition
  5. 5. Genomic approach
  6. 6. Personalized Medicine
  7. 7. Protein-protein interaction
  8. 8. Public & private partnerships

Detailed course structure

  1. 1. Positioning of the main key concerns related to Environment issues
  2. 2. Reminders and basic knowledge related to waste management
  3. 3. Focus on biological treatment routes
  4. 4. Contaminated soils bioremediation
  5. 5. Contributions of biotechnology processes to Biofuels production and CO2 conversion into biomass
  6. 6. Case applicative exercise

General objectives of education

Be able to understand the work to be conducted to prepare, execute, finalize and report the results of a clinical trial with a view of the regulatory landscape, industrial, logistical and financial domain.

Detailed course structure

  1. 1. Context
  2. 2. Managing clinical trials
  3. 3. Conclusion and practice

MINOR BIOINFORMATICS

General objectives of education

Acquire basic knowledge in the protein engineering and in silico protein design for enzyme activity optimization, increase thermal and catalytic activity

Detailed course structure

  1. 1. Basic of Molecular Modeling
  2. 2. Statistical modeling in Cheminformatics
  3. 3. Docking and Virtual Screening

General objectives of education

Acquire basic knowledge in system biology and analysis of biological networks, especially metabolic network. First introduction to biological dynamical systems using Ordinary Differential Equation (ODE) to study the time evolution of biochemical reaction networks and to simulate cell growth. Optimization techniques will be applied on metabolic networks for finding pathway that optimize a given objective function (biomass or production of a set of metabolites).

Detailed course structure

  1. 1. Population dynamics
  2. 2. Biochemical Reaction Networks

General objectives of education

Acquire basic knowledge in the four main theme of genomic bioinformatics: i) Genome and metagenome, speciation and phylogeny, ii) Population genotype and annotation, iii) DNA study for medicine and epidemiology, biomarkers for rare and common diseases, analysis of single nucleotide polymorphism iv) RNA : transcriptomics, regulation by transcription factors.

Detailed course structure

  1. 1. Genome and Metagenome
  2. 2. Genetic of Populations
  3. 3. Diseased-related Genetic Biomarkers
  4. 4. RNA and Transcriptomics

Entrepreneurship

General objectives of education

The proposed approaches are based on the complementary application of entrepreneurial design tools, design thinking and the ' implementation '. Design thinking is a mode of application design tools used by designers to solve a problem of innovation, by a multi-disciplinary approach centered on humans. Design thinking is a cyclical, iterative method, alternation of observation and design, abstraction and concrete, wealth of ideas and their elimination for the exploration of a prototype. Design thinking requires a permanent synthesis between the analytical skills of the engineers and marketing professionals, and the intuitive skills of creative. Effectuation is based on a mode of reasoning based on the human, intellectual and social capital resources made by the entrepreneur. The combination of these resources creates possible, not predetermined objectives (degree of unpredictability), built during the entrepreneurial process. Professional recruitment candidates for this program submit a letter of intent for maintenance of motivation. They are audited before an internal jury to Sup 'Biotech in order to assess personality, desire and potential entrepreneur, the business opportunity and consistency with the Sup school' Biotech

Detailed course structure

  • Module 1: Tools entrepreneurs
  • Module 2: Choice of the project
  • Module 3: Project team
  • Module 4: Market research
  • Module 5: Economic models of innovation
  • Module 7: Finance innovation, be accompanied
  • Module 8: Marketing plan
  • Module 9: The business development plan
  • Module 10: Communicate with its target
  • Module 11: Modes of financing
  • Module 12: Evaluation of the Pitch
  • Module 13: Fundraising - Business Angels

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